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1

Discovery of 3-(3-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051-a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia

Takahiro Sato, Naoki Ashizawa, Koji Matsumoto, Takashi Iwanaga, Hiroshi Nakamura, Tsutomu Inoue, Osamu Nagata

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.71 MB

english, 2009

2

Laughter Regulates Gene Expression in Patients with Type 2 Diabetes

Hayashi, Takashi, Urayama, Osamu, Kawai, Koichi, Hayashi, Keiko, Iwanaga, Shizuko, Ohta, Masayuki, Saito, Toshiro, Murakami, Kazuo

Journal:

Psychotherapy and Psychosomatics

Year:

2006

Language:

english

File:

PDF, 115 KB

english, 2006

3

Association between single nucleotide polymorphisms in estrogen receptor 1/2 genes and symptomatic severity of autism spectrum disorder

Doi, Hirokazu, Fujisawa, Takashi X., Iwanaga, Ryoichiro, Matsuzaki, Junko, Kawasaki, Chisato, Tochigi, Mamoru, Sasaki, Tsukasa, Kato, Nobumasa, Shinohara, Kazuyuki

Journal:

Research in Developmental Disabilities

Year:

2018

Language:

english

File:

PDF, 191 KB

english, 2018

4

Effects of suplatast tosilate (IPD Capsules®) on the production of active oxygen by neutrophils and of IL-8 by mononuclear cells

Yuji Tohda, Hirokazu Kubo, Ryuta Haraguchi, Takashi Iwanaga, Masahiro Fukuoka

Journal:

International Immunopharmacology

Year:

2001

Language:

english

File:

PDF, 71 KB

english, 2001

5

Palladium-Catalyzed ortho -Selective CH Borylation of 2-Phenylpyridine and Its Derivatives at Room Temperature

Kuninobu, Yoichiro, Iwanaga, Takashi, Omura, Tetsuya, Takai, Kazuhiko

Journal:

Angewandte Chemie International Edition

Year:

2013

Language:

english

File:

PDF, 368 KB

english, 2013

6

[IEEE 2012 International Conference on Renewable Energy Research and Applications (ICRERA) - Nagasaki, Japan (2012.11.11-2012.11.14)] 2012 International Conference on Renewable Energy Research and Applications (ICRERA) - Analysis of a segment type switched reluctance generator for wind power generation

Iwanaga, Takashi, Fukumoto, Sho, Higuchi, Tsuyoshi, Yokoi, Yuichi, Abe, Takashi

Year:

2012

Language:

english

File:

PDF, 447 KB

english, 2012

7

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California - ()] D42. COPD TREATMENT: OXYGEN, HOME VENTILATION AND OTHERS - Effect Of Protcaterol "Assist Use" On Quality Of Life And Exercise Capacity In Patients With Chronic Obstructive Pulmonary Disease

Higashimoto, Yuji, Miyajima, Hiroyuki, Ichihashi, Hideo, Sano, Akiko, Satoh, Ryuji, Nishiyama, Osamu, Sano, Hiroyuki, Yamagata, Toshiyuki, Iwanaga, Takashi, Nakajima, Hirokazu, Tomita, Katsuyuki, Kume

Year:

2012

Language:

english

File:

PDF, 18 KB

english, 2012

8

Laughter therapy modulates the parameters of renin-angiotensin system in patients with type 2 diabetes

Nasir, Uddin, Iwanaga, Shizuko, Nabi, A., Urayama, Osamu, Hayashi, Keiko, Hayashi, Takashi, Kawai, Koichi, Sultana, Afroza, Murakami, Kazuo, Suzuki, Fumiaki

Journal:

International Journal of Molecular Medicine

Year:

2005

Language:

english

File:

PDF, 1.32 MB

english, 2005

9

Scanning Electron Microscopic Observation of Apical Sites of Open-Type Paraneurons in the Stomach, Intestine and Urethra.

HASHIMOTO, Yoshiharu, USHIKI, Tatsuo, UCHIDA, Takashi, YAMADA, Junzo, IWANAGA, Toshihiko

Journal:

Archives of Histology and Cytology

Year:

1999

File:

PDF, 1.08 MB

1999

10

Analysis of clinical symptoms and ABCC6 mutations in 76 Japanese patients with pseudoxanthoma elasticum

Iwanaga, Akira, Okubo, Yumi, Yozaki, Mariko, Koike, Yuta, Kuwatsuka, Yutaka, Tomimura, Saori, Yamamoto, Yosuke, Tamura, Hiroshi, Ikeda, Satoshi, Maemura, Koji, Tsuiki, Eiko, Kitaoka, Takashi, Endo, Yu

Journal:

The Journal of Dermatology

Year:

2017

Language:

english

File:

PDF, 223 KB

english, 2017

11

Clinical features of nasal and sinonasal inverted papilloma associated with malignancy

Miyazaki, Takuya, Haku, Yasuharu, Yoshizawa, Akira, Iwanaga, Ken, Fujiwara, Takashi, Mizuta, Masanobu, Yoshida, Atsuhiro, Satou, Shinichi, Tamaki, Hisanobu

Journal:

Auris Nasus Larynx

Year:

2018

Language:

english

File:

PDF, 235 KB

english, 2018

12

Correlation between Sensory Good Taste and Chemical Compositions in Natural and Mineral Water

SASAKI, Ken, IWANAGA, Chihiro, WATANABE, Masanori, SUZUKI, Kojiro, HAMAOKA, Takashi, KONDO, Susumu

Journal:

Journal of the agricultural chemical society of Japan

Year:

1996

File:

PDF, 1.03 MB

1996

13

Association of Aryl Hydrocarbon Receptor-Related Gene Variants with the Severity of Autism Spectrum Disorders

Fujisawa, Takashi X., Nishitani, Shota, Iwanaga, Ryoichiro, Matsuzaki, Junko, Kawasaki, Chisato, Tochigi, Mamoru, Sasaki, Tsukasa, Kato, Nobumasa, Shinohara, Kazuyuki

Journal:

Frontiers in Psychiatry

Year:

2016

Language:

english

File:

PDF, 292 KB

english, 2016

14

Improvement of Blood Pressure Control by Adherence Check in Patients With Apparent Treatment-Resistant Hypertension: A Case Series

Hosohata, Keiko, Inada, Ayaka, Oyama, Saki, Doi, Takashi, Niinomi, Iku, Wakabayashi, Tomohito, Uchida, Mayako, Iwanaga, Kazunori, Matsuoka, Hiroyuki

Journal:

Clinical Medicine Insights Case Reports

Year:

2020

File:

PDF, 350 KB

2020

15

Functional role of phosphatidylcholine-specific phospholipase C in regulating leukotriene synthesis and degranulation in human eosinophils

Sano, Akiko, Sano, Hiroyuki, Iwanaga, Takashi, Tohda, Yuji

Journal:

European Journal of Pharmacology

Year:

2020

File:

PDF, 2.13 MB

2020

16

Challenges faced in managing adult asthma: A perspective from Asian countries

Dhar, Raja, Ip, Mary, Kulkarni, Tarang, Kim, SangâHeon, Perng, DiahnâWarng, Yao, Xin, Iwanaga, Takashi, Siyue Koh, Mariko

Journal:

Year:

2020

File:

PDF, 370 KB

2020

17

Assessment of serum CYFRA 21-1 in lung cancer

Masato Muraki, Yuji Tohda, Takashi Iwanaga, Hisao Uejima, Yukio Nagasaka, Shigenori Nakajima

Journal:

Year:

1996

Language:

english

File:

PDF, 391 KB

english, 1996

18

Synchronous and metachronous primary gastric lymphoma and adenocarcinoma : A clinicopathologic study of 12 patients

Shotaro Nakamura, Kunihiko Aoyagi, Shin-ichi Iwanaga, Takashi Yao, Masazumi Tsuneyoshi, Masatoshi Fujishima

Journal:

Year:

1997

Language:

english

File:

PDF, 558 KB

english, 1997

19

Possible association between adult T-cell leukemia/Lymphoma and acute myeloid leukemia

Kunihiro Tsukasaki, Takashi Koba, Masako Iwanaga, Ken Murata, Takahiro Maeda, Sunao Atogami, Hideo Nakamura, Yasuaki Yamada, Shimeru Kamihira, Masao Tomonaga

Journal:

Year:

1998

Language:

english

File:

PDF, 85 KB

english, 1998

20

Ovarian relapse seven years after bone marrow transplantation for B-cell acute lymphoblastic leukemia: An unusual Krukenberg tumor

Takashi Sonoki, Eisaku Iwanaga, Hiroaki Mitsuya, Norio Asou

Journal:

American Journal of Hematology

Year:

2005

Language:

english

File:

PDF, 103 KB

english, 2005

21

ChemInform Abstract: Discovery of 3-(3-Cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051 — A Xanthine Oxidoreductase Inhibitor for the Treatment of Hyperuricemia.

Takahiro Sato, Naoki Ashizawa, Koji Matsumoto, Takashi Iwanaga, Hiroshi Nakamura, Tsutomu Inoue, Osamu Nagata

Journal:

Year:

2010

File:

PDF, 17 KB

2010

22

ChemInform Abstract: Rhenium-Catalyzed Regioselective Synthesis of Phenol Derivatives from 1,3-Diesters and Terminal Alkynes.

Yoichiro Kuninobu, Takashi Iwanaga, Mitsumi Nishi, Kazuhiko Takai

Journal:

Year:

2011

File:

PDF, 42 KB

2011

23

Optical resolution of unusual amino acids using microbial proteases

Toshifumi Miyazawa, Hitoshi Iwanaga, Takashi Yamada, Shigeru Kuwata

Journal:

Year:

1992

Language:

english

File:

PDF, 572 KB

english, 1992

24

Critical role of the N-terminal cyclic AMP-binding domain of Epac2 in its subcellular localization and function

Manabu Niimura, Takashi Miki, Tadao Shibasaki, Wakako Fujimoto, Toshihiko Iwanaga, Susumu Seino

Journal:

Journal of Cellular Physiology

Year:

2009

Language:

english

File:

PDF, 276 KB

english, 2009

25

Corrigendum to “Discovery of 3-(2-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051 – a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia” [Bioorg. Med. Chem. Lett. 19 (2009) 6225]

Takahiro Sato, Naoki Ashizawa, Koji Matsumoto, Takashi Iwanaga, Hiroshi Nakamura, Tsutomu Inoue, Osamu Nagata

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 105 KB

english, 2010

26

Design, synthesis, and pharmacological and pharmacokinetic evaluation of 3-phenyl-5-pyridyl-1,2,4-triazole derivatives as xanthine oxidoreductase inhibitors

Takahiro Sato, Naoki Ashizawa, Takashi Iwanaga, Hiroshi Nakamura, Koji Matsumoto, Tsutomu Inoue, Osamu Nagata

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.41 MB

english, 2009

27

Resistance to experimental colitis depends on cytoprotective heat shock proteins in macrophage migration inhibitory factor null mice

Tatsuya Ohkawara, Jun Nishihira, Yoh Ishiguro, Eiji Otsubo, Koichi Nagai, Hiroshi Takeda, Mototsugu Kato, Takashi Yoshiki, Toshihiko Iwanaga, Masahiro Asaka

Journal:

Immunology Letters

Year:

2006

Language:

english

File:

PDF, 625 KB

english, 2006

28

Roles of histamine receptor in a guinea pig asthma model

Yuji Tohda, Hirokazu Kubo, Ryuta Haraguchi, Takashi Iwanaga, Masahiro Fukuoka, Shigenori Nakajima

Journal:

International Journal of Immunopharmacology

Year:

1998

Language:

english

File:

PDF, 234 KB

english, 1998

29

Inhibitory effect of TMK-688 on late asthmatic responses as well as T-cell and eosinophilic infiltration in guinea pigs with asthmatic reactions

Yuji Tohda, Masato Muraki, Akinobu Kawai, Takashi Iwanaga, Hirokazu Kubo, Masahiro Fukuoka, Sigenori Nakajima

Journal:

International Journal of Immunopharmacology

Year:

2000

Language:

english

File:

PDF, 730 KB

english, 2000

30

Resolution of non-protein amino acids via the enantioselective hydrolysis of their esters mediated by sulfhydryl proteases

Toshifumi Miyazawa, Hitoshi Iwanaga, Takashi Yamada, Shigeru Kuwata

Journal:

Biotechnology Letters

Year:

1994

Language:

english

File:

PDF, 350 KB

english, 1994

31

Study on species differences in nephropathy induced by FYX-051, a xanthine oxidoreductase inhibitor

Takeo Shimo, Naoki Ashizawa, Mitsuyoshi Moto, Takashi Iwanaga, Osamu Nagata

Journal:

Archives of Toxicology

Year:

2011

Language:

english

File:

PDF, 561 KB

english, 2011

32

Application of transmission scan-based attenuation compensation to scatter-corrected thallium-201 myocardial single-photon emission tomographic images

Jun Hashimoto, Koichi Ogawa, Atsushi Kubo, Takashi Ichihara, Nobutoku Motomura, Takuzo Takayama, Shiro Iwanaga, Hideo Mitamura, Satoshi Ogawa

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Year:

1998

Language:

english

File:

PDF, 1.11 MB

english, 1998

33

Sporadic amyotrophic lateral sclerosis of long duration is associated with relatively mild TDP-43 pathology

Yasushi Nishihira, Chun-Feng Tan, Yasuhiro Hoshi, Keisuke Iwanaga, Megumi Yamada, Izumi Kawachi, Mitsuhiro Tsujihata, Isao Hozumi, Takashi Morita, Osamu Onodera, Masatoyo Nishizawa, Akiyoshi Kakita, H

Journal:

Acta Neuropathologica

Year:

2009

Language:

english

File:

PDF, 614 KB

english, 2009

34

Sporadic four-repeat tauopathy with frontotemporal lobar degeneration, Parkinsonism, and motor neuron disease: a distinct clinicopathological and biochemical disease entity

Yong-Juan Fu, Yasushi Nishihira, Shigetoshi Kuroda, Yasuko Toyoshima, Tomohiko Ishihara, Makoto Shinozaki, Akinori Miyashita, Yue-Shan Piao, Chun-Feng Tan, Takashi Tani, Ryoko Koike, Keisuke Iwanaga,

Journal:

Acta Neuropathologica

Year:

2010

Language:

english

File:

PDF, 1.15 MB

english, 2010

35

Roles of double-balloon endoscopy in the diagnosis and treatment of Crohn’s disease: a multicenter experience

Jumpei Kondo, Hideki Iijima, Takashi Abe, Masato Komori, Satoshi Hiyama, Toshifumi Ito, Akihiro Nakama, Kouhei Tominaga, Mitsuhiko Kubo, Kunio Suzuki, Yoshihisa Iwanaga, Ryoichi Ebara, Akira Takeda, S

Journal:

Journal of Gastroenterology

Year:

2010

Language:

english

File:

PDF, 198 KB

english, 2010

36

Nephronophthisis in two siblings

Mamiko Ashizawa, Masanobu Miyazaki, Akira Furusu, Katsushige Abe, Yasuhide Kanamoto, Nobuaki Iwanaga, Yoshiyuki Ozono, Takashi Harada, Takashi Taguchi, Shigeru Kohno

Journal:

Clinical and Experimental Nephrology

Year:

2005

Language:

english

File:

PDF, 383 KB

english, 2005

37

Macular retinal detachment associated with peripapillary detachment in pathologic myopia

Noriaki Shimada, Kyoko Ohno-Matsui, Yoichi Iwanaga, Takashi Tokoro, Manabu Mochizuki

Journal:

International Ophthalmology

Year:

2009

Language:

english

File:

PDF, 279 KB

english, 2009

38

Characterization of Hepatobiliary Transport Systems of a Novelα4β1/α4β7 Dual Antagonist, TR-14035

Minoru Tsuda-Tsukimoto, Tomoji Maeda, Takashi Iwanaga, Toshiyuki Kume, Ikumi Tamai

Journal:

Pharmaceutical Research

Year:

2006

Language:

english

File:

PDF, 665 KB

english, 2006

39

Predominant Contribution of Rat Organic Anion Transporting Polypeptide-2 (Oatp2) to Hepatic Uptake of β-Lactam Antibiotics

Masanori Nakakariya, Taiki Shimada, Masanori Irokawa, Hiroyuki Koibuchi, Takashi Iwanaga, Hikaru Yabuuchi, Tomoji Maeda, Ikumi Tamai

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 368 KB

english, 2008

40

Involvement of Uric Acid Transporters in Alteration of Serum Uric Acid Level by Angiotensin II Receptor Blockers

Masanobu Sato, Takashi Iwanaga, Hideaki Mamada, Toshio Ogihara, Hikaru Yabuuchi, Tomoji Maeda, Ikumi Tamai

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 542 KB

english, 2008

41

Clinical and inflammatory factors associated with body mass index in elderly patients with chronic obstructive pulmonary disease

Higashimoto Yuji, Yamagata Toshiyuki, Honda Noritsugu, Satoh Ryuji, Sano Hiroyuki, Iwanaga Takashi, Miyara Takayuki, Muraki Masato, Tomita Katsuyuki, Tohda Yuji, Fukuda Kanji

Journal:

Geriatrics & Gerontology International

Year:

2011

Language:

english

File:

PDF, 221 KB

english, 2011

42

Tissue factor pathway inhibitor is highly susceptible to chymase-mediated proteolysis

Tsutomu Hamuro, Hiroshi Kido, Yujiro Asada, Kinta Hatakeyama, Yuushi Okumura, Youichi Kunori, Takashi Kamimura, Sadaaki Iwanaga, Shintaro Kamei

Journal:

Year:

2007

Language:

english

File:

PDF, 836 KB

english, 2007

43

10.1038/35041046

Seino, Susumu, Ozaki, Nobuaki, Shibasaki, Tadao, Kashima, Yasushige, Miki, Takashi, Takahashi, Kazuo, Ueno, Hiroaki, Sunaga, Yasuhiro, Yano, Hideki, Matsuura, Yoshiharu, Iwanaga, Toshihiko, Takai, Yos

Journal:

Nature Cell Biology

Year:

2000

Language:

english

File:

PDF, 358 KB

english, 2000

44

Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1

Miki, Takashi, Suzuki, Masashi, Shibasaki, Tadao, Uemura, Hiroko, Sato, Toshiaki, Yamaguchi, Kaori, Koseki, Haruhiko, Iwanaga, Toshihiko, Nakaya, Haruaki, Seino, Susumu

Journal:

Nature Medicine

Year:

2002

Language:

english

File:

PDF, 671 KB

english, 2002

45

An Experimental Study on the Pharmacokinetics of 5-Fluorouracil Regional Chemotherapy for Pancreatic Cancer

Masaaki Mitsutsuji, Yasuyuki Suzuki, Yasuhiro Iwanaga, Yasuhiro Fujino, Yasuki Tanioka, Takashi Kamigaki, Yonson Ku, Yoshikazu Kuroda

Journal:

Annals of Surgical Oncology

Year:

2003

Language:

english

File:

PDF, 109 KB

english, 2003

46

Immunocytochemical study on the localization of neuron-specific enolase and S-100 protein in the carotid body of rats

Hisatake Kondo, Toshihiko Iwanaga, Takashi Nakajima

Journal:

Cell and Tissue Research

Year:

1982

Language:

english

File:

PDF, 1.20 MB

english, 1982

47

An immunocytochemical study on the localization of S-100 protein in the retina of rats

Hisatake Kondo, Toshihiko Iwanaga, Takashi Nakajima

Journal:

Cell and Tissue Research

Year:

1983

Language:

english

File:

PDF, 1.69 MB

english, 1983

48

Structure and function relationship of staphylocoagulase

Shun-Ichiro Kawabata, Takashi Morita, Toshiyuki Miyata, Shigenori Kaida, Sadaaki Iwanaga, Hideo Igarashi

Journal:

The Protein Journal

Year:

1987

Language:

english

File:

PDF, 841 KB

english, 1987

49

The hemolymph coagulation system in invertebrate animals

Sadaaki Iwanaga, Takashi Morita, Toshiyuki Miyata, Takanori Nakamura, Jun Aketagawa

Journal:

The Protein Journal

Year:

1986

Language:

english

File:

PDF, 1.48 MB

english, 1986

50

Amino acid sequence of chicken fibrinopeptide A

Takashi Takagi, J.S. Finlayson, Sadaaki Iwanaga

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure

Year:

1978

Language:

english

File:

PDF, 236 KB

english, 1978

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